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Sigma
Azaserine
A4142 -
≥98% (TLC)
DOWNLOAD MSDS (PDF)Synonym: O-Diazoacetyl-
CAS Number: 115-02-6
Empirical Formula (Hill Notation): C5H7N3O4
Molecular Weight: 173.13
Beilstein Registry Number: 1726602
EC Number: 204-061-6
MDL number: MFCD00036802
PubChem Substance ID: 24890830
Properties
| Related Categories | Amino Acid Derivatives, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, |
| assay | ≥98% (TLC) |
| storage temp. | −20°C |
Description
Application
Used in cell culture for the selection of HGPRT revertants.
Biochem/physiol Actions
Azaserine is an antibiotic and antifungal; it may also act as a tumor inducer. It is a structural analog of glutamine and competes with glutamine in binding to enzymes involved in purine biosynthesis. Azaserine inhibits purine biosynthesis by covalently reacting with cysteine residues in the enzyme active sites, such as in formylglycinamide ribonucleotide amidotransferase and PRPP amidotransferase.1 Azaserine can induce DNA damage via the formation of carboxymethylated bases and O6-methylguanine. Secretion of exo-1,3-β-glucanase and germ-tube formation of Candida albicans were inhibited by azaserine.2
Price and Availability
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Documents
Certificate of Analysis
Certificate of Origin
| A4142 - Product Information Sheet (26 KB) |
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Safety Information
| Symbol |   GHS06, GHS08 |
| Signal word | Danger |
| Hazard statements | H301-H351 |
| Precautionary statements | P281-P301 + P310 |
| Personal Protective Equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Statements | 25-40 |
| Safety Statements | 53-36/37/39-45 |
| RIDADR | UN 3462 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | VT9625000 |
Technical information & documentation associated with this product is available in the Safety & Documentation tab.
References
1. Kornberg, A., and Baker, T. DNA Replication 2ndth ed.,, (1992), 57-60, 440-442
2. Ram, S.P., et al., Exo-(1→3)-β-glucanase, autolysin and trehalase activities during yeast growth and germ-tube formation in Candida albicans. J. Gen. Microbiol. 130, 1227, (1984) Abstract
Merck 14,899
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